Hubungan Derajat Keasaman Cairan Lambung dengan Derajat Dispepsia pada Pasien Dispepsia Fungsional

Abstract

Abstrak

Hipersekresi asam lambung dianggap penting sebagai salah satu mekanisme patologis dispepsia fungsional. Hipersekresi asam lambung dapat meningkatkan sekresi pepsin yang dapat menimbulkan kerusakan mukosa lambung pada dispepsia fungsional. Tujuan penelitian ini adalah menentukan hubungan derajat keasaman cairan lambung dengan derajat dispepsia yang dialami pasien dispepsia fungsional. Penelitian ini merupakan studi analitik dengan disain cross sectional yang dilakukan pada 35 sampel pasien dispepsia fungsional dengan teknik consecutive sampling di RSUP DR. M.Djamil Padang mulai Juli sampai Oktober 2014. Analisis data dilakukan secara komputerisasi menggunakan uji chi-square. Hasil penelitian didapatkan 51.4% pasien dispepsia fungsional memiliki derajat keasaman cairan lambung hyperacidity, 57.1% menderita dispepsia derajat sedang-berat, dan menunjukkan hubungan yang cukup kuat dengan tarif signifikansi (p) 0.029 (p < 0.05). Terdapat hubungan bermakna antara derajat keasaman cairan lambung dengan derajat dispepsia pada pasien dispepsia fungsional. Peningkatan derajat keasaman cairan lambung berbanding lurus dengan derajat dispepsia pada pasien dispepsia fungsional.

Kata kunci: keasaman cairan lambung, derajat dispepsia, dispepsia fungsional

Abstract

Gastric acid hypersecretion is considered important as one of the pathological mechanisms of functional dyspepsia. Gastric acid hypersecretion can increase the secretion of pepsin which can cause gastric mucosal damage in functional dyspepsia. The objective of this study was to determine the correlation of gastric juice acidity with dyspepsia level experienced by functional dyspepsia patients.This study was a analytic study with cross sectional design applied on 35 samples of functional dyspepsia patients with non-probability consecutive sampling technique at RSUP DR. M. Djamil Padang from July to October 2014. The data were computerized analyzed using chi-square test. The results showed 51.4% of patients with functional dyspepsia had hyperacidity gastric juice, 57.1% had moderate-to-severe dyspepsia level, and show a strong enough correlation with the rate of significance  0.029 (p < 0.05).There was a significant correlation between the gastric juice acidity with dyspepsia level of functional dyspepsia patients. Increase of gastric juice acidity is proportional to the dyspepsia level in functional dyspepsia patients.

Keywords::gastric juice acidity, dyspepsia level, functional dyspepsia