Perbedaan Kadar C-Reactive Protein Serum Ibu pada Kehamilan Aterm Ketuban Pecah Dini dan Kehamilan Normal

Debby Yolanda, Ariadi Ariadi, Nur Indrawati Lipoeto

Abstract

Abstrak
Kehamilan dengan Ketuban Pecah Dini (KPD) masih merupakan masalah penting dalam bidang obstetri, karena berkaitan dengan penyulit atau komplikasi yang dapat meningkatkan morbiditas serta mortalitas maternal dan perinatal. Salah satu faktor risiko KPD yaitu infeksi. C-reactive protein (CRP) merupakan salah satu protein yang meningkat pada saat terjadi infeksi. Tujuan penelitian ini adalah  menentukan perbedaan kadar CRP serum ibu pada kehamilan aterm KPD dan normal. Penelitian ini merupakan penelitian observasional dengan rancangan cross
sectional. Dilaksanakan di Ruang Kebidanan RSUD Dr. Achmad Mochtar Bukittinggi tahun 2014. Sampel penelitian ini adalah ibu hamil aterm dengan jumlah 60 orang yang diambil dengan Consecutive Sampling, sampel dibagi menjadi 2 kelompok yaitu ibu hamil ketuban pecah dini dan ibu hamil normal. Pemeriksaan kadar CRP dengan menggunakan
metode ELISA. Data dianalisa menggunakan t-test independent, dan nilai p<0.05 dianggap bermakna secara statistik. Rerata kadar CRP serum pada kelompok KPD adalah 12,40±0,70 dan pada kelompok hamil normal adalah 6,44+2,36. Hasil uji independen t-test menunjukan terdapat perbedaan bermakna rerata kadar CRP serum antara kelompok KPD
dengan kelompok kehamilan normal (p<0,05).
Kata Kunci: C-reactive protein, ketuban pecah dini, kehamilan normal

Abstract
Pregnancy with prematur rupture of membrane (PROM) still become an important matter in obstetric, as it relates to complication which can increase maternal and perinatal morbidity and mortality. Infection is one of many risk factors of PROM. C-reactive protein is a protein which elevated when there is an infection. The objective of this study was to determine the difference of maternal C - reactive protein serum levels in term pregnancy with prematur rupture of membrane and normal pregnancy. This is an observational study with cross-sectional design. This study takes place in maternity room of RSUD Dr. Achmad Mochtar Bukittinggi in 2014. Samples in this study are 60 aterm pregnant women which have been chosen by consecutive sampling, samples divided with pregnant women with PROM and normal pregnant women. CRP levels measured with ELISA method. Data were analyzed using analysis of
independent t-test, and p<0.05 was considered to be significantly different. CRP serum levels mean in term pregnancy with PROM group is 12.40±0.70 and in normal pregnancy group is 6.44+2.36. Independent t-test analysis showed that there was significant difference of maternal C - reactive protein serum levels between in term pregnancy with PROM
and normal pregnancy with p value < 0.05.
Keywords: C – reactive protein, preterm rupture of membrane, normal pregnancy


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