Peran Kemokin dalam Patogenesis Rinitis Alergi

Authors

  • Effy Huriyati
  • Bestari J Budiman
  • Ricki Octiza

DOI:

https://doi.org/10.25077/jka.v3i2.101

Abstract

Abstrak
Latar belakang: Rinitis alergi merupakan penyakit dengan insiden yang cukup tinggi diseluruh dunia dengan prevalensi yang semakin meningkat setiap tahun. Patogenesis rinitis alergi melibatkan reaksi imun yang cukup komplek. Tujuan: Mengetahui peranan kemotaktik sitokin (Kemokin) dalam patogenesis rinitis alergi. Tinjauan pustaka: Kemokin sebagai kemotaktik sitokin berperan dalam semua tahap reaksi alergi. CC kemokin merupakan subfamili kemokin yang berperan dalam reaksi alergi. Kemokin bekerja pada permukaan sel-sel inflamasi berikatan dengan reseptor. CCR3 merupakan reseptor dengan kadar tertinggi yang ditemukan pada permukaan eosinofil dan eotaxin sebagai ligand yang spesifik bagi CCR3. Kesimpulan: Eotaxin dan reseptor CCR3 adalah faktor yang paling menonjol dalam patogenesis rinitis alergi yang melibatkan eosinophil
Kata kunci: Reaksi alergi, Th2, CC Kemokin, eosinofil, CCR3

 

Abstract

Background: Allergic rhinitis such a disease with high incidence among the world and its prevalence appears to be increasing every year. The pathogenesis of allergic rhinitis commit complex imunological reaction. Purpose: To know the role of chemotactic cytokine (chemokine) in pathogenesis of allergic rhinitis. Literature review: Chemokine as a chemotactics cytokine participate to all allergic reaction stage. CC chemokines were subfamilial chemokines which have role in allergic reaction. They working by binding with receptor on the surface of inflamatory cells. CCR3 is the receptor with the highes level could be found on eosinophil cell membran and eotaxin was the spesific ligand to itt. Conclusion: Eotaxin and CCR3 are the major factor in pathogenesis of allergic rhinitis which is involve eosinophil.
Keywords: Allergic reaction, Th2, CC Chemokines, eosinophil, CCR3

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Published

2014-05-01

How to Cite

Huriyati, E., Budiman, B. J., & Octiza, R. (2014). Peran Kemokin dalam Patogenesis Rinitis Alergi. Jurnal Kesehatan Andalas, 3(2). https://doi.org/10.25077/jka.v3i2.101

Issue

Vol. 3 No. 2 (2014)

Section

Literature Review

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