Infeksi Cacing dan Alergi

Authors

  • Selfi Renita Rusdji

DOI:

https://doi.org/10.25077/jka.v4i1.241

Abstract

Abstrak
Infeksi cacing masih merupakan masalah kesehatan di Indonesia dan negara berkembang lainnya. Penyakit ini sering terjadi di daerah dengan higienisitas dan sanitasi yang masih kurang. Respon imun tubuh host terhadap cacing ini mirip dengan respon tubuh terhadap penyakit alergi. Respon pada penyakit kecacingan dan alergi ini merupakan respon Thelper2 yaitu diferensiasi dan polariasasi sel limfosit T lebih dominan pada Th2. Pada kenyataannya, ditinjau dari segi epidemiologi, penyakit kecacingan dan penyakit alergi terdapat pada daerah yang sangat berbeda. Prevalensi penyakit alergi cenderung lebih banyak terjadi di daerah maju dengan higiene dan sanitasi yang baik. Keadaan ini menimbulkan pertanyaan apakah kecacingan mempunyai efek proteksi terhadap manifestasi klinis berbagai macam penyakit alergi. Hygiene hypothesis merupakan teori yang relevan dalam menjawab pertanyaan ini. Mekanisme yang dapat menerangkan fenomena ada adalah saturasi sel mast, penghambatan oleh IgG4 dan modified Th2 response.
Kata kunci: infeksi cacing, alergi, respon Th2

Abstract
Helminthiasis is still unsolved problem in Indonesia and other developing countries. This disease is frequently occurred in poor personal hygiene and environmental sanitation. The human immune response to helminth infections is similar with response to allergic disease. These disease present T helper2 (Th2) response which characterized dominant differentiation and proliferation of Th2. In fact, epidemiology study shows that they are occurred in different type of region. High prevalence of allergic disease is found in modern country which is well established sanitation and good personal hygiene. This condition raises fundamental question whether helminthiasis is associated with protection against allergic disease. Hygiene hypothesis is a theory that can explain this phenomen. The mechanisms are mast cell saturation, IgG4 blocking and modified Th2.
Keywords: helminthiasis, allergy, Th2 response

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Published

2015-01-01

How to Cite

Rusdji, S. R. (2015). Infeksi Cacing dan Alergi. Jurnal Kesehatan Andalas, 4(1). https://doi.org/10.25077/jka.v4i1.241

Issue

Vol. 4 No. 1 (2015)

Section

Literature Review

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