Gambaran Pemeriksaan Kadar SGOT, SGPT, Ureum dan Kreatinin Pasien Covid-19 dengan dan tanpa Komorbid

Authors

  • Rachmi Fadillah RSUP Dr. M.Djamil, Padang.
  • Ellyza Nasrul Bagian Patologi Klinik dan Kedokteran Laboratorium, Fakultas Kedokteran, Universitas Andalas, Padang.
  • Tuty Prihandani Bagian Patologi Klinik dan Kedokteran Laboratorium, Fakultas Kedokteran, Universitas Andalas, Padang.

DOI:

https://doi.org/10.25077/jka.v10i2.1722

Abstract

Coronavirus disease (COVID-19) causes damage through mechanisms: cytotoxic to the bile duct, liver and renal tubular epithelial cells; severe inflammatory response due to excessive pro-inflammatory cytokines (cytokine storm); tissue anoxia; and drug-induced liver and kidney damage. AST and ALT enzymes are used to determine liver damage, while kidney damage is examined from increased urea and creatinine levels. Objectives: To know AST, ALT, urea and creatinine levels in COVID-19 patients with and without comorbidity in RSUP Dr. M. Djamil Padang. Methods: A retrospective descriptive study was conducted by taking chemical data for COVID-19 patients with and without comorbidity for March-August 2020. AST and ALT levels were examined by using an automatic chemistry analyzer with NADH method (without P-5'-P), urea with enzymatic colorimetry, and creatinine with Jaffe's modification. The data was presented in table and average (standard deviation). Results:  A study of 76 patients found 28 with comorbidity and 48 without comorbidity. Patients with comorbidity AST in average was 33.0 (20.3) U/l; SGPT 29.0 (23.4) U/l; urea 58.3 (66.9) mg/dl; and creatinine 3.0 (5.1) mg/dl. Patients without comorbidity AST in average 31.9 (28.7) mg/dl; SGPT 28.8 (21.4) mg/dl; urea 24.6 (20.1) mg/dl; creatinine 0.9 (0.4) mg/dl. In average, AST and ALT in patients with and without comorbidity were in the normal range. Urea and creatinine in patients with comorbidity were higher than normal. Conclusion: Covid-19 patients with comorbidity at admission had urea and creatinine levels in average higher than normal values.

Keywords: aminotransaminase, COVID-19, creatinine

Downloads

Published

2021-09-12 — Updated on 2025-03-22

Versions

How to Cite

Fadillah, R., Nasrul, E., & Prihandani, T. (2025). Gambaran Pemeriksaan Kadar SGOT, SGPT, Ureum dan Kreatinin Pasien Covid-19 dengan dan tanpa Komorbid. Jurnal Kesehatan Andalas, 10(2), 107–113. https://doi.org/10.25077/jka.v10i2.1722 (Original work published September 12, 2021)

Issue

Vol. 10 No. 2 (2021): Online July 2021

Section

Research Articles

License

Copyright (c) 2021 Rachmi Fadillah

Creative Commons License

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Authors retain copyright and grant the Jurnal Kesehatan Andalas right of first publication with the work simultaneously licensed under a Creative Commons Attribution-ShareAlike (CC BY-SA 4.0) license that allows others to share (copy and redistribute the material in any medium or format) and adapt (remix, transform, and build upon the material) the work for any purpose, even commercially with an acknowledgement of the work's authorship and initial publication in Jurnal Kesehatan Andalas.

Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in Jurnal Kesehatan Andalas.

Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).